Ricinoleate medicament for internal use



Patented Nov. 5, 1935 I RICINOLEATE MEDICAMENT FOR INTERNAL USE TheodoreH. Rider, Cincinnati, Ohio, assignor to The Wm. S. Men-ell Company,Cincinnati, Ohio, a corporation of Ohio,

No Drawing. Application October 30, 1933, Serial No. 695,846

6 Claims. (CL 167-68) The present invention relates to a therapeutic bemade by a variety of reactions, the art of which substance and has foran object the provision of is relatively well known. For the purposes ofmeans to establish a method of producing inthis invention, it ispreferable to prepare these testinal detoxification withoutobjectionable salts from a purified ricinoleic acid or from detaste andstomach irritation. rivatives thereof. It is known that ricinoleic 5These and other objects are obtained by the acid may be reacted withcalcium or magnesium. hereinafter described means. hydroxide. It is alsopossible to prepare these Itis known that sodium ricinoleate, whenadsalts by double decomposition of water soluble ministered orally,exerts a detoxifying action in calcium or magnesium salts and sodiumricinole- 10 the various portions of the intestine and preate. Theinvention herein is not to be considered vents reactions resulting fromthe absorption of limited to any specific method or methods of toxicmaterials of bacterial and other origin. preparing the salts or to anyspecific method or Oral administration of sodium ricinoleate hasmethods, of therapeutic use but rather to the two highly undesirablefeatures, namely, the obprovision of water insoluble salts, especiallycaljectionable taste and the irritating action in the cium andmagnesium, for attaining the beneficial 15 stomach. The administrationof the water soludetoxification of sodium ricinoleate. An efiecblesodium ricinoleate therefore while having tive product for the purposesstated may be made the proven beneficial properties is neverthelessaccording to the following illustration, it being an undesirable methodof intestinal detoxificaund rstood that th q an i i f h n redi nts gotion uniess contact of the sodium ricinoleate with are subject tovariation within wide limits. One the mouth or stomach is prevented.thousand (1000) pounds of colloidal kaolin or any The invention consistsin providing a means similar insoluble, inert, colloidal solid aresuswhereby the beneficial action of sodium ricinolepended in water andone hundred (100) pounds ate is attained at the desired place, namely,in of ricinoleic acid is added and thoroughly mixed.

the intestine, although the substance adminis- A slight excess over thetheoretical amount of 25 tered is not sodium ricinoleate. magnesium (orcalcium) hydrate is then stirred It has been proven that the waterinsoluble in vigorously. The magnesium ricinoleate presalts ofricinoleic acid do not have the objecpared in this way remains veryfinely divided and tionable taste. This is specifically true of caltheresulting suspension may be used as such if oium and magnesiumricinoleate in suspension desired. The suspension prepared in this way30 in a neutral solution. Acids are found to liberate is furthermorecapable of being emulsified with ricinoleic acid from calcium andmagnesium rimineral oil with any of the customary emulsifycinoleatesregenerating an objectionable taste and ing agents. l a compound whichis irritating to the stomach. The medicinal products prepared in theman- It has also been found that 'dilute alkalis dissolve ner outline bythe formation of calcium or mag- 35 a portion of the calcium andmagnesium ricinolenesium ricinoleate in the presence of colloidal ates,yielding sodium ricinoleate. Thus the mixkaolin especially afteremulsification with mining of milk of magnesia with a solution of sodiumeral oil can be taken into the stomach with imricinoleate fails tocompletely precipitate the p n y Since the emulsion is not broken ydmix- 40 ricinoleate. Conversely, the calcium or magture with diluteacid such as found in the stomo nesium ricinoleates if introduced intoan alkaline ach, and since the acid of the stomach will not medium,viz., the intestine, liberate sodium produce such liberation of sodiumricinoleate as ricinoleate. Therefore the insoluble salts of to producestomach irritation.

ricinoleic acid, particularly the calcium and mag- What is claimed is:

nesium salts thereof are suitable as detoxifying 1. A therapeuticcompound for oral adminis- 45 agents for the intestine or for anycondition tration for intestinal detoxification comprising where aslight alkalinity exists. These salts may a water insoluble salt fromthe group consisting be taken orally either as suspensions in fluids, orof calcium ricinoleate and magnesium ricinoleate. in capsules oremulsions. When the salts are 2. A medicament for oral administrationfor so taken without media to protect them from stomintestinaldetoxification comprising an insoluble ach acidity, they should bewashed through rapidricinoleate from the group consisting of calcium 1y.The protection is advisable for comfort but ricinoleate and magnesiumricinoleate in a state is not required to maintain therapeutic activity.of fine division in suspension with a solid inert The magnesium andcalcium ricinoleates, in colloid in suspension.

common with other heavy metal ricinoleates, may 3. A therapeutic agentfor oral administration 55 for intestinal detoxiilcation comprisingcalcium ricinoleate.

4. A therapeutic agent for oral administration i'ormtestinaldetoxiilcation comprising magnesicomprising a water insolublesalt of ricinoleate acid selected from the group consisting 01 calciumricinoleate and magnesium ricinoleate in suspension in a neutralcolloidal solution.

aoiaoss, I

8. The method of preparing a medication comprising a water insolublesalt selected from the group consisting of the calcium and magnesiumsalts of ricinoleic acid which consists in preparingandmaintainingsaidsaltsinastateotflne division through the reaction 01 the hydrate oithe cation with ricinoleic acid in the presence of a suspensionoianinsolubleinertsoiidinacolloidal state.

THEODORE H. RIDER. 1o

